Hussong's Cantina is the oldest and best known cantina in all of Mexico. It is also the oldest cantina in the Californias (California in the United States and Baja California in Mexico).

The original Hussong's is located in Ensenada, Baja California, Mexico, and was established in 1892. The second Hussong's Cantina opened in Las Vegas, Nevada USA in January 2009.

Hussong's is reputedly the place where the Margarita was created in October, 1941 by bartender Don Carlos Orozco. He concocted a mixture of equal parts tequila, Damiana (Cointreau is used now) and lime, served over ice in a salt-rimmed glass for Margarita Henkel, daughter of the German Ambassador to Mexico